Current state of second trimester screening for Down's syndrome
نویسندگان
چکیده
منابع مشابه
Screening for Down syndrome in the second trimester of pregnancy.
Antenatal screening for fetal anomalies has provided women and their partners with information to make reproductive choices based on the risk of serious chromosomal or structural defects since the 1990s. Alternative tests include first-trimester screening (combined ultrasound and maternal serum markers), second-trimester maternal serum markers and noninvasive cell-free DNA testing. The recent r...
متن کاملRole of second-trimester genetic sonography after Down syndrome screening.
OBJECTIVE To estimate the effectiveness of second-trimester genetic sonography in modifying Down syndrome screening test results. METHODS The First and Second Trimester Evaluation of Risk (FASTER) aneuploidy screening trial participants were studied from 13 centers where a 15- to 23-week genetic sonogram was performed in the same center. Midtrimester Down syndrome risks were estimated for fiv...
متن کاملFirst-trimester or second-trimester screening, or both, for Down's syndrome.
BACKGROUND It is uncertain how best to screen pregnant women for the presence of fetal Down's syndrome: to perform first-trimester screening, to perform second-trimester screening, or to use strategies incorporating measurements in both trimesters. METHODS Women with singleton pregnancies underwent first-trimester combined screening (measurement of nuchal translucency, pregnancy-associated pl...
متن کاملFirst-trimester screening for Down's syndrome.
The aim of the present study was to evaluate the efficacy of the first trimester screening for Down syndrome (DS) in an unselected low-risk Finnish population. The study involved 4,617 women who attended screening between the 8th and 14th weeks of pregnancy in 1998-2000. They gave a blood sample for the measurement of pregnancy associated plasma protein A (PAPP-A) and free beta human chorionic ...
متن کاملScreening for Down's syndrome: effects, safety, and cost effectiveness of first and second trimester strategies.
OBJECTIVE To compare the effects, safety, and cost effectiveness of antenatal screening strategies for Down's syndrome. DESIGN Analysis of incremental cost effectiveness. SETTING United Kingdom. MAIN OUTCOME MEASURES Number of liveborn babies with Down's syndrome, miscarriages due to chorionic villus sampling or amniocentesis, health care costs of screening programme, and additional costs...
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ژورنال
عنوان ژورنال: Journal of Medical Screening
سال: 1998
ISSN: 0969-1413,1475-5793
DOI: 10.1136/jms.5.3.113